“Melanogenic Metaplasia” of Mucous Glands

Mucous metaplasia of the pleura.

A case of mucous metaplasia of mesothelium in an 80 year old woman is described. Its cause is unknown, but it is important not to confuse it with secondary tumour.

Oncocytes in human bronchial mucous glands.

Oncocytes were found in the bronchial glands of 30 of 33 lungs in which the left bronchial tree was examined. They were found with similar frequency in the main, upper and lower lobe bronchi. They were found more commonly with increasing age and were most frequent in the collecting duct of the bronchial glands. However, they were absent from the collecting duct in 14 cases. They were not increa...

The Role of Atoh1 in Mucous Cell Metaplasia

A key issue in otitis media is mucous cell metaplasia which is responsible for mucous hypersecretion and persistence of the disease. However, little is known about the molecular mechanisms of mucous cell metaplasia in otitis media. Numerous studies of intestinal epithelial homeostasis have shown that Atonal homolog 1 (Atoh1), a basic helix-loop-helix (bHLH) transcription factor, is essential fo...

Immunogenetic programs for viral induction of mucous cell metaplasia.

Mucous secretions are frequently implicated in the morbidity and mortality associated with respiratory illness and airway disease, but we still do not understand precisely how these secretions develop or how to control them. A likely possibility is that the increased mucus is a consequence of overproduction and subsequent secretion in the setting of mucous cell metaplasia. In that regard, airwa...

Mucous Metaplasia and Airways Neonatal Rhinovirus Infection Induces